When we are controlled by our sinful nature it is impossible to please God.
Romans 8:7-11 “For the sinful nature is always hostile to God. It never did obey God’s laws, and it never will. 8 That’s why those who are still under the control of their sinful nature can never please God. … 9 But you are not controlled by your sinful nature. You are controlled by the Spirit … so even though your body will die because of sin, the Spirit gives you life … 11 The Spirit of God, who raised Jesus from the dead, lives in you. And just as God raised Christ Jesus from the dead, he will give life to your mortal bodies by this same Spirit living within you.”
Lord take me when I am used up, but use me until I am taken.